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Cambridge University Press
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Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental and molecular biology; chemical and material sciences (i.e. nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. This book will draw attention to the critical role that pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. The first state-of-the-art book in this rapidly evolving field of research. |
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Now established as the indispensable formulary in psychopharmacology, this latest edition of The Prescriber's Guide has been completely revised and updated to reflect the most current practice in the use of psychotropic drugs. Easy to navigate and easy to use, The Prescriber's Guide combines evidence-based information with clinically informed guidance to support clinicians in making the most effective prescribing decisions for the good of their patients. With coverage of twelve brand-new drugs — including antidepressants, antipsychotics, hypnotics, nonstimulants for ADHD, and medical foods — and incorporating information on the newest indications, new formulations, new recommendations, and new safety data, this edition continues to provide the essential practical support required by anyone prescribing in the field of mental health. |
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After expanding steadily for centuries, science is reaching its limits to growth. We can no longer afford the ever increasing cost of exploring ever wider research opportunities. In the competition for resources, science is becoming much more tightly organised. A radical, pervasive and permanent structural change is taking place. It already affects the whole research system, from everyday laboratory life to national budgets. The scientific enterprise cannot avoid fundamental change, but excessive managerial insistence on accountability, evaluation, priority setting, etc. can be very inhospitable to expertise, innovation, criticism and creativity. Can the research system be reshaped without losing many features that have made science so productive? This trenchant analysis of a deep-rooted historical process does not assume any technical knowledge of the natural sciences, their history, philosophy, sociology or politics. It is addressed to everybody who is concerned about the future of science and its place in society. |
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Planned parenthood — and its associated reproductive and sexual healthcare issues — has massive socioeconomic and demographic consequences worldwide. Modern contraception played a major role in the emancipation of women and has huge potential for a sustainable future world population. Yet it is a medical topic which always raises controversy, with serious ethical, religious and cultural overtones. This is an authoritative guide for all those working in reproductive healthcare. Highly practical, evidence-based, with enough detail to inform effective clinical practice, the book is structured on a lifestage approach, mirroring everyday experience of practitioners. All forms of contraceptives are covered in detail, with guidance on prescribing, the advantages and disadvantages of various techniques, and possible complications. The wider field of reproductive healthcare including subfertility and sexual assault are also covered. An ideal guide to contraception for trainees in obstetrics and gynaecology, primary care physicians and nurse-practitioners. |
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This book covers all of the important elements of paediatric anaesthesia in a concise and structured manner. From the premature infant to the teenager, readers are guided through the complexities they may encounter, with key points at the end of each chapter to summarise the most important information. The common surgical conditions encountered in daily practice are covered along with comprehensive discussion of consent and the law, safeguarding children, and the complexity of drug dosing in the paediatric population. Other topics covered include trauma, burns, resuscitation, principles of intensive care, and transporting a sick child. Each chapter is written by an acknowledged expert in their field, sharing a wealth of relevant, practical experience. Covering the whole curriculum necessary for advanced training, this is essential reading for trainees, general anaesthetists managing children in non-specialist hospitals and anyone aspiring to become a paediatric anaesthetist, as well as those established in the field. |
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This volume is part of the definitive edition of letters written by and to Charles Darwin, the most celebrated naturalist of the nineteenth century. Notes and appendixes put these fascinating and wide-ranging letters in context, making the letters accessible to both scholars and general readers. Darwin depended on correspondence to collect data from all over the world and to discuss his emerging ideas with scientific colleagues, many of whom he never met in person. The letters are published chronologically: volume 20 includes letters from 1872, the year in which The Expression of the Emotions in Man and Animals was published, making ground-breaking use of photography. Also in this year, the sixth and final edition of On the Origin of Species was published and Darwin resumed his work on carnivorous plants and plant movement, finding unexpected similarities between the plant and animal kingdoms. |
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The three volumes of A Course in Mathematical Analysis provide a full and detailed account of all those elements of real and complex analysis that an undergraduate mathematics student can expect to encounter in their first two or three years of study. Containing hundreds of exercises, examples and applications, these books will become an invaluable resource for both students and teachers. Volume I focuses on the analysis of real-valued functions of a real variable. This second volume goes on to consider metric and topological spaces. Topics such as completeness, compactness and connectedness are developed, with emphasis on their applications to analysis. This leads to the theory of functions of several variables. Differential manifolds in Euclidean space are introduced in a final chapter, which includes an account of Lagrange multipliers and a detailed proof of the divergence theorem. Volume III covers complex analysis and the theory of measure and integration. |
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This introductory textbook provides students with a system-level perspective and the tools they need to understand, analyze and design digital systems. Going beyond the design of simple combinational and sequential modules, it shows how such modules are used to build complete systems, reflecting real-world digital design. All the essential topics are covered, including design and analysis of combinational and sequential modules, as well as system timing and synchronization. It also teaches how to write Verilog HDL in a productive and maintainable style that enables CAD tools to do much of the tedious work. A complete introduction to digital design is given through clear explanations, extensive examples and online Verilog files. The teaching package is completed with lecture slides, labs and a solutions manual for instructors. Assuming no previous digital knowledge, this textbook is ideal for undergraduate digital design courses that will prepare students for modern digital practice. |
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Debate over the meaning of 'Enlightenment' began in the eighteenth century and still continues to this day. This period saw the opening of arguments on the nature of man, truth, the place of God and the international circulation of ideas, people and gold. But did the Enlightenment mean the same for men and women, for rich and poor, for Europeans and non-Europeans? In the third edition of her acclaimed book, Dorinda Outram addresses these and other questions about the Enlightenment as controversy increases about its place at the foundation of modernity. She studies it as a global phenomenon, setting the period against broader social changes. This new edition offers a new chapter on political economy, a completely revised further reading section and a new feature on electronic sources to stimulate primary research. This accessible overview will be essential reading for students of eighteenth-century history, philosophy and the history of ideas. |
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In recent years, the study of formal semantics and formal pragmatics has grown tremendously, showing that core aspects of language meaning can be explained by few principles. These principles are grounded in the logic that is behind — and tightly intertwined — with the grammar of human language. In this book, some of the most prominent figures in linguistics, including Noam Chomsky and Barbara H. Partee, offer new insights into the nature of linguistic meaning and pave the way for the further development of formal semantics and formal pragmatics. Each chapter investigates various dimensions in which the logical nature of human language manifests itself within a language and/or across languages. Phenomena like bare plurals, free choice items, scalar implicatures, intervention effects and logical operators are investigated in depth and at times cross-linguistically and/or experimentally. This volume will be of interest to scholars working within the fields of semantics, pragmatics, language acquisition and psycholinguistics. |
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This comprehensive introduction to the principles of functional programming using F# shows how to apply basic theoretical concepts to produce succinct and elegant programs. It demonstrates the role of functional programming in a wide spectrum of applications including databases and systems. Coverage also includes advanced features in the .NET library, the imperative features of F# and topics such as text processing, sequences, computation expressions and asynchronous computation. With a broad spectrum of examples and exercises, the book is perfect for courses in functional programming and for self-study. Enhancing its use as a text is an accompanying website with downloadable programs, lecture slides, mini-projects and links to further F# sources. |
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God, Sexuality and the Self is a new venture in systematic theology. Sarah Coakley invites the reader to re-conceive the relation of sexual desire and the desire for God and — through the lens of prayer practice — to chart the intrinsic connection of this relation to a theology of the Trinity. The goal is to integrate the demanding ascetical undertaking of prayer with the recovery of lost and neglected materials from the tradition and thus to reanimate doctrinal reflection both imaginatively and spiritually. What emerges is a vision of human longing for the triune God which is both edgy and compelling: Coakley's theologie totale questions standard shibboleths on 'sexuality' and 'gender' and thereby suggests a way beyond current destructive impasses in the churches. The book is clearly and accessibly written and will be of great interest to all scholars and students of theology. |
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The Handbook on Systemic Risk, written by experts in the field, provides researchers with an introduction to the multifaceted aspects of systemic risks facing the global financial markets. The Handbook explores the multidisciplinary approaches to analyzing this risk, the data requirements for further research, and the recommendations being made to avert financial crisis. The Handbook is designed to encourage new researchers to investigate a topic with immense societal implications as well as to provide, for those already actively involved within their own academic discipline, an introduction to the research being undertaken in other disciplines. Each chapter in the Handbook will provide researchers with a superior introduction to the field and with references to more advanced research articles. It is the hope of the editors that this Handbook will stimulate greater interdisciplinary academic research on the critically important topic of systemic risk in the global financial markets. |
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A transistor-level, design-intensive overview of high speed and high frequency monolithic integrated circuits for wireless and broadband systems from 2 GHz to 200 GHz, this comprehensive text covers high-speed, RF, mm-wave and optical fiber circuits using nanoscale CMOS, SiGe BiCMOS and III-V technologies. Step-by-step design methodologies, end-of-chapter problems and practical simulation and design projects are provided, making this an ideal resource for senior undergraduate and graduate courses in circuit design. With an emphasis on device-circuit topology interaction and optimization, it gives circuit designers and students alike an in-depth understanding of device structures and process limitations affecting circuit performance. |
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How did the zebra really get its stripes, and the giraffe its long neck? What is the science behind camel humps, leopard spots, and other animal oddities? Such questions have fascinated us for centuries, but the expanding field of evo-devo (evolutionary developmental biology) is now providing, for the first time, a wealth of insights and answers. Taking inspiration from Kipling's Just So Stories, this book weaves emerging insights from evo-devo into a narrative that provides startling explanations for the origin and evolution of traits across the animal kingdom. Held's unique and engaging style makes this narrative both enlightening and entertaining, guiding students and researchers through even complex concepts and encouraging a fuller understanding of the latest developments in the field. The first five chapters cover the first bilaterally symmetric animals, flies, butterflies, snakes, and cheetahs. A final chapter surveys recent results about a menagerie of other animals. |
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How can actuaries best equip themselves for the products and risk structures of the future? In this groundbreaking textbook, three leaders in actuarial science give a modern perspective on life contingencies. The book begins with actuarial models and theory, emphasizing practical applications using computational techniques. The authors then develop a more contemporary outlook, introducing multiple state models, emerging cash flows and embedded options. This expanded edition contains more examples and exercises, and brand new material on discrete time Markov processes, on models involving joint lives, and on universal life insurance and participating traditional insurance. Balancing rigour with intuition, and emphasising applications, this textbook is ideal for university courses, for qualified actuaries wishing to update their skills, and for individuals preparing for professional actuarial examinations. The book covers the entire Society of Actuaries MLC syllabus and will be especially valuable for students preparing for the new, long answer style exam questions. |
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Since Mill's seminal work On Liberty, philosophers and political theorists have accepted that we should respect the decisions of individual agents when those decisions affect no one other than themselves. Indeed, to respect autonomy is often understood to be the chief way to bear witness to the intrinsic value of persons. In this book, Sarah Conly rejects the idea of autonomy as inviolable. Drawing on sources from behavioural economics and social psychology, she argues that we are so often irrational in making our decisions that our autonomous choices often undercut the achievement of our own goals. Thus in many cases it would advance our goals more effectively if government were to prevent us from acting in accordance with our decisions. Her argument challenges widely held views of moral agency, democratic values and the public/private distinction, and will interest readers in ethics, political philosophy, political theory and philosophy of law. |
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Disorders of the ovary can lead to a wide range of endocrinologic and malignant conditions, many of which are linked with fertility. This comprehensive, yet succinct book presents a multidisciplinary approach to address the major issues in diagnosing and managing ovarian disorders. Beginning with the complex functioning of the normal ovary, the editors address many of the major issues in women's health. New chapters on ovarian cysts, menopause, the aging ovary, early detection and risk assessment of ovarian cancer, screening, stage I ovarian cancer and many other topics have been added to this third edition. Assisted reproductive techniques, diagnostic imaging modalities, minimally invasive surgery, and chemotherapy have advanced dramatically and the chapters have been updated accordingly. This well-documented volume has been fully updated with contemporary references and chapters written by current leaders in their field. A must-read for gynecologists, oncologists, obstetricians, pathologists and researchers in human reproductive sciences. |
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Master the basic concepts and methodologies of digital signal processing with this systematic introduction, without the need for an extensive mathematical background. The authors lead the reader through the fundamental mathematical principles underlying the operation of key signal processing techniques, providing simple arguments and cases rather than detailed general proofs. Coverage of practical implementation, discussion of the limitations of particular methods and plentiful MATLAB illustrations allow readers to better connect theory and practice. A focus on algorithms that are of theoretical importance or useful in real-world applications ensures that students cover material relevant to engineering practice, and equips students and practitioners alike with the basic principles necessary to apply DSP techniques to a variety of applications. Chapters include worked examples, problems and computer experiments, helping students to absorb the material they have just read. Lecture slides for all figures and solutions to the numerous problems are available to instructors. |
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Rapid recognition of life-threatening illnesses and injuries expedites appropriate management and improves clinical outcomes. False-positive interpretations in radiology have been identified as a significant cause of error, leading to unnecessary investigation and treatment, increased healthcare costs, and delays in appropriate management. Moreover, it is important that radiologists do not miss important subtle diagnoses that need urgent intervention. Pearls and Pitfalls in Emergency Radiology provides an outline of common imaging artefacts, anatomic variants and critical diagnoses that the radiologist must master in order to guide appropriate care and avoid malpractice lawsuits. One hundred selected cases — illustrated with several hundred images from MRI, MDCT, PET, ultrasound and radiographs — are presented in a succinct and structured format, highlighting key pearls and potential diagnostic pitfalls. The text focuses on emergent presentations of diseases in all body regions in both adults and children. |
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